Scaling Factor Threshold Estimator in Different Color Models Using a Discrete Wavelet Transform for Steganographic Algorithm

Two of the main problems with steganographic algorithms are insertion capability and minimization of distortion in the digital files where the hidden information is the information is inserted to hiding Digital filters are generally used as noise detectors, and they also suppress information outside the original information contained in the file. There are different types of filtering, one in the spatial domain and the other in the frequency domain or sometimes a combination of both domains to propose adaptive filters. One of the filters with greater application is the discrete wavelet transform (DWT) because it is easy to implement and has low computational complexity. The DWT computationally implemented in an image can be represented as a quadrature mirror filter, separating the frequency components: so high-high, high-low, low-high and low-low levels obtain different resolutions

Mobile Distributed User Interfaces

The success of a mobile application is due to the usability that the graphical user interface provides. A feature of mobile devices is the limited space for the interaction and the deployment of the graphical user interface. For this reason, user interfaces can have different interaction modalities. However, to work with information that can be complex to display, the use of modalities may not solve this problem. A possible alternative to provide more workspace to the users is through a distributed user interface (DUI). A mobile DUI allows the mobile applications to use two or more devices to execute the user interface. These devices can be Smart TVs or wearable such as smart watches. In this work the concepts of mobile DUI design are discussed, some use cases are presented and it is shown that its development in mobile devices is feasible

Diseño para el desarrollo sustentable y la habitabilidad segura e incluyente

Este libro se divide en dos partes que permiten permear en el campo de la enseñanza del diseño; la primera se enfoca en temáticas que se desprenden del diseño en la educación para la sustentabilidad; en la segunda, se identifican las tendencias del diseño como un modo de verlo y sentirlo: va desde el diseño emocional hacia uno de conservación, reúso y reparación de objetos para reducir el consumo de recursos materiales

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field

The global retinoblastoma outcome study : a prospective, cluster-based analysis of 4064 patients from 149 countries

DATA SHARING : The study data will become available online once all analyses are complete.BACKGROUND : Retinoblastoma is the most common intraocular cancer worldwide. There is some evidence to suggest that major differences exist in treatment outcomes for children with retinoblastoma from different regions, but these differences have not been assessed on a global scale. We aimed to report 3-year outcomes for children with retinoblastoma globally and to investigate factors associated with survival. METHODS : We did a prospective cluster-based analysis of treatment-naive patients with retinoblastoma who were diagnosed between Jan 1, 2017, and Dec 31, 2017, then treated and followed up for 3 years. Patients were recruited from 260 specialised treatment centres worldwide. Data were obtained from participating centres on primary and additional treatments, duration of follow-up, metastasis, eye globe salvage, and survival outcome. We analysed time to death and time to enucleation with Cox regression models. FINDINGS : The cohort included 4064 children from 149 countries. The median age at diagnosis was 23·2 months (IQR 11·0–36·5). Extraocular tumour spread (cT4 of the cTNMH classification) at diagnosis was reported in five (0·8%) of 636 children from high-income countries, 55 (5·4%) of 1027 children from upper-middle-income countries, 342 (19·7%) of 1738 children from lower-middle-income countries, and 196 (42·9%) of 457 children from low-income countries. Enucleation surgery was available for all children and intravenous chemotherapy was available for 4014 (98·8%) of 4064 children. The 3-year survival rate was 99·5% (95% CI 98·8–100·0) for children from high-income countries, 91·2% (89·5–93·0) for children from upper-middle-income countries, 80·3% (78·3–82·3) for children from lower-middle-income countries, and 57·3% (52·1-63·0) for children from low-income countries. On analysis, independent factors for worse survival were residence in low-income countries compared to high-income countries (hazard ratio 16·67; 95% CI 4·76–50·00), cT4 advanced tumour compared to cT1 (8·98; 4·44–18·18), and older age at diagnosis in children up to 3 years (1·38 per year; 1·23–1·56). For children aged 3–7 years, the mortality risk decreased slightly (p=0·0104 for the change in slope). INTERPRETATION : This study, estimated to include approximately half of all new retinoblastoma cases worldwide in 2017, shows profound inequity in survival of children depending on the national income level of their country of residence. In high-income countries, death from retinoblastoma is rare, whereas in low-income countries estimated 3-year survival is just over 50%. Although essential treatments are available in nearly all countries, early diagnosis and treatment in low-income countries are key to improving survival outcomes.The Queen Elizabeth Diamond Jubilee Trust and the Wellcome Trust.https://www.thelancet.com/journals/langlo/homeam2023Paediatrics and Child Healt

DESARROLLO DEL PENSAMIENTO PROBABILÍSTICO EMPLEANDO TECNOLOGÍA EN ESTUDIANTES DE INGENIERÍA

La comprensión conceptual en probabilidad todavía parece ser una tarea difícil, cargada de ambigüedad, en que por un lado, los eventos probabilísticos quieren ser tratados como los determinísticos, al tratar los estudiantes de usar exclusivamente fórmulas. Es necesario que el maestro involucre actividades que le permitan conocer el nivel cognitivo y los procesos de pensamiento de sus alumnos, de tal forma que pueda implementar tareas para desarrollar en ellos su pensamiento probabilístico. El presente trabajo muestra dos fases de un proyecto de investigación, desarrollado en el IPN. La primera es de tipo exploratoria, y la segunda fase es de desarrollo. La exploratoria estuvo centrada en realizar un diagnóstico del pensamiento probabilístico de los estudiantes de nivel superior, frente a tareas que involucran situaciones de azar. Para ello, se diseñó un cuestionario para 226 estudiantes de cuarto semestre de ingeniería. Para el análisis se tomó en cuenta la categorización de las respuestas de los estudiantes, basadas en los niveles cognitivos del modelo SOLO (Structure of the Observed Learning Outocome). Con base en lo obtenido, se determinó que la posición que asumen los estudiantes frente a situaciones de aleatoriedad está basada, generalmente, en sus intuiciones personales. En la segunda fase se desarrollaron estrategias didácticas empleando recursos tecnológicos como el uso de simulaciones para la enseñanza de la Probabilidad y Estadística. Estas simulaciones permitieron que el estudiante visualizara diversas situaciones, que al desarrollarlas en el salón de clases consumirían demasiado tiempo o serían complicadas de realizar